Melanoma genetics
نویسندگان
چکیده
منابع مشابه
Melanoma genetics.
Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of heritable melanoma risk genes is an important component of disease occurrence. Susceptibility for some fam...
متن کاملGenetics of melanoma
Genomic variation is a trend observed in various human diseases including cancer. Genetic studies have set out to understand how and why these variations result in cancer, why some populations are pre-disposed to the disease, and also how genetics affect drug responses. The melanoma incidence has been increasing at an alarming rate worldwide. The burden posed by melanoma has made it a necessity...
متن کاملGenetics of Uveal Melanoma
Uveal melanoma is the most common type of primary eye cancer in adults, affecting 0.7/100,000 of the Western population yearly (Egan et al., 1988). The melanoma originates from neural crest derived melanocytes of the uvea (choroid, ciliary body and iris) and despite enucleation or conservative treatment half of patients die of, most often late appearing, metastatic disease (15-year survival: 53...
متن کاملMelanoma Genetics/Genomics
Gene mutations represent a major driving force in the onset and progression of melanoma. Consequently many genes are being investigated for their role in melanomagenesis, including not only inherited genes but also genetic defects that are acquired due to environmental factors, such as excessive sun exposure. The field of melanoma genetics thus encompasses genes in familial melanoma through to ...
متن کاملClinical genetics of melanoma
Malignant melanoma (MM) represents one of the most aggressive neoplasms and its frequency is increasing rapidly. Increased melanoma risk among relatives of MM patients and familial aggregations of this malignancy point at genetic predisposition as an important factor of MM pathogenesis. The genetic basis of MM is complex and appears to involve multiple genes. CDKN2A is regarded as the major MM ...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 2015
ISSN: 0022-2593,1468-6244
DOI: 10.1136/jmedgenet-2015-103150